Evolving mortality rates in people who inject drugs: An Australian tertiary hospital observational study on infective endocarditis.

Autor: Isa Khan, Elizabeth Brookes, John Santamaria, Daniel Crisafi, Andrew Wilson, Jonathan Darby, Andrew Newcomb
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: PLoS ONE, Vol 17, Iss 8, p e0270283 (2022)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0270283
Popis: BackgroundInjection drug use (IDU) associated infective endocarditis (IE) is clinically challenging due to social issues this population endures. Rates of IDU are rising globally, however, there is a lack of clear guidelines for IDU associated IE. The aim of this study is to assess the epidemiology of the IDU and non-IDU populations and compare their long-term outcomes to help guide future management.MethodsAn observational cohort study was conducted on all 350 patients treated for IE at St Vincent's Hospital Melbourne between 1999 and 2015. Follow up was performed until death or January 2021. Primary outcome was all-cause mortality.ResultsIDU patients are younger (pConclusionDespite having higher levels of reinfection, IDU patients have better long-term survival compared to non-IDU patients. Therefore, we suggest IDU patients should not have blanket restrictions on the management they are offered unless at the individual level there is a contraindication to therapy.
Databáze: Directory of Open Access Journals
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