Effect of S-PRG Eluate on Biofilm Formation and Enzyme Activity of Oral Bacteria

Autor: Masahiro Yoneda, Nao Suzuki, Yosuke Masuo, Akie Fujimoto, Kosaku Iha, Kazuhiko Yamada, Tomoyuki Iwamoto, Takao Hirofuji
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Zdroj: International Journal of Dentistry, Vol 2012 (2012)
Druh dokumentu: article
ISSN: 1687-8728
1687-8736
DOI: 10.1155/2012/814913
Popis: Recently, the antibacterial activity of a composite resin containing prereacted glass ionomer (S-PRG) filler was revealed. We examined the effect of an S-PRG eluate on various biologic activities of Streptococcus mutans and Porphyromonas gingivalis. Adherence ability of S. mutans was evaluated by microtiter plate assay; protease and gelatinase activities of P. gingivalis were examined by synthetic substrate hydrolysis and gelatin film spot assay, respectively. Coaggregation of P. gingivalis with Fusobacterium nucleatum was also examined. S-PRG eluate was found to suppress streptococcal adherence. S-PRG eluate inhibited the protease and gelatinase activities of P. gingivalis and the coaggregation between P. gingivalis and F. nucleatum. These results indicate that S-PRG eluate suppresses streptococcal adherence and inhibits the protease and coaggregation activities of P. gingivalis. These findings may prompt research into novel strategies for preventing caries and periodontitis.
Databáze: Directory of Open Access Journals
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