Epidermal hydration and skin surface lipids in patients with long-term complications of sulfur mustard poisoning
| Autor: | Pouran Layegh, Masoud Maleki, Seyed Reza Mousavi, Hadis Yousefzadeh, Akram Momenzadeh, Shiva Golmohammadzadeh, Mahdi Balali-Mood |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Journal of Research in Medical Sciences, Vol 20, Iss 7, Pp 640-645 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1735-1995 1735-7136 |
| DOI: | 10.4103/1735-1995.166200 |
| Popis: | Background: Despite almost the three decades passed since the chemical attacks of Iraqi′s army against the Iranian troops, some veterans are still suffering from long-term complications of sulfur mustard (SM) poisoning, including certain skin complaints specially dryness, burning, and pruritus. We thus aimed to evaluate the skin′s water and lipid content in patients with a disability of >25% due to complications of SM poisoning and compare them with a matched control group. Materials and Methods: Sixty-nine male participants were included in this study; 43 SM-exposed patients, and 26 normal controls from their close relatives. The water and lipid content was measured in four different locations: Extensor and flexor sides of forearms and lateral and medial sides of legs by the Corneometer CM 820/Sebumeter SM 810. Collected data was analyzed and P ≤ 0.05 was considered as statistically significant. Results: The mean age of the patients and controls was 49.53 ± 11.34 (ranges: 40-71) and 29.08 ± 8.836 (ranges: 15-49 years), respectively. In the veterans group, the main cutaneous complaint was itching and skin dryness. Cherry angioma, dry skin, and pruritus were significantly more common in the SM-exposed cases than in the controls. (P = 0.01, 0.05, and 0.04, respectively). The moisture and lipid content of all areas were lower in the SM-exposed group, but it was only significant in skin sebum of lateral sides of legs (P = 0.02). Conclusion: Exposure to SM could decrease the function of stratum corneum and lipid production as a barrier, even after several years of its exposure. |
| Databáze: | Directory of Open Access Journals |
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