| Autor: |
Alexandra Lahtinen, Antti Häkkinen, Sampsa Puttonen, Päivi Vanttola, Katriina Viitasalo, Tarja Porkka-Heiskanen, Mikko Härmä, Tiina Paunio |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-82627-0 |
| Popis: |
Abstract The human DNA methylome is responsive to our environment, but its dynamics remain underexplored. We investigated the temporal changes to DNA methylation (DNAme) in relation to recovery from a shift work disorder (SWD) by performing a paired epigenome-wide analysis in an occupational cohort of 32 shift workers (25 men, age = 43.8 ± 8.8 years, 21 SWD cases). We found that the effect of vacation on DNAme was more prominent in the SWD-group as compared to controls, with respect to the amount of significantly differentially methylated positions (DMPs; P unadj |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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