Correlation of Ki-67 and MCM-2 proliferative marker expression with grade of histological malignancy (G) in ductal breast cancers.
| Autor: | Marzena Podhorska-Okolow, Bartosz Pula, Anna Krolicka, Christopher Kobierzycki, Andrzej Wojnar, Piotr Dziegiel |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Folia Histochemica et Cytobiologica, Vol 48, Iss 3, Pp 442-446 (2010) |
| Druh dokumentu: | article |
| ISSN: | 0239-8508 1897-5631 |
| DOI: | 10.5603/4196 |
| Popis: | The study aimed at examining a relationship between expression of Ki-67 antigen and minichromosome maintenance 2 protein (MCM-2) and a grade of histological malignancy G in ductal breast cancers. The function of widely used marker of proliferation Ki-67 is still not clear. In contrast, the MCM-2 protein is well known to play an important role in controlling the cell cycle. Both proteins represent small protein molecules, which manifest nuclear expression only during cell division of normal and neoplastic cells. Their expression is noted in several malignant tumours. These studies were conducted on 56 archival paraffin blocks of ductal breast cancers. Immunohistochemical reactions were performed using monoclonal Ki-67- and MCM-2-specific antibodies. Statistical analysis demonstrated a positive correlation between expressions of two proteins (r=0.6; p |
| Databáze: | Directory of Open Access Journals |
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