Glutathione system participation on neutrophils functional status during acute inflammation
| Autor: | T. V. Zhavoronok |
|---|---|
| Jazyk: | English<br />Russian |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Бюллетень сибирской медицины, Vol 9, Iss 5, Pp 28-31 (2010) |
| Druh dokumentu: | article |
| ISSN: | 1682-0363 1819-3684 |
| DOI: | 10.20538/1682-0363-2010-5-28-31 |
| Popis: | There was conducted the study of glutathione system status (the content of reduced, oxidized, protein-bound glutathione, SHgroups of proteins and glutathionperoxydase activity) and functional properties (the production of hydroxyl radical, IL-8, TNF-α and myeloperoxidase activity) of neutrophils received from people with community-acquired pneumonia. There was revealed the role of reduced and protein-bound glutathione in the regulation of myeloperoxidase activity and production of hydroxyl radical by blood neutrophils when incubating cells with glutathione synthesis blocker de novo (buthioninesulfoximine). and catalase inhibitor (3-amino-1,2,4-triazole). It was ascertained that glutathione synthesis de novo is more important than catalase activity (inhibition by 3-amino 1,2,4-triasole) to support neutrophil functional condition. |
| Databáze: | Directory of Open Access Journals |
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