| Autor: |
Hazem Mohamed Salamah, Ahmed Marey, Esraa Elsayed, Mohammed Tarek Hasan, Abdelrahman Mahmoud, Khaled Alsayed Abualkhair, Dina Essam Abo-elnour, Ibrahim Abdelmonaem Abdelhaleem, Mohamed Abd-Elgawad |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-023-46274-x |
| Popis: |
Abstract Polyethylene glycol loxenatide (PEX168) is a novel glucagon-like peptide-1 receptor agonist with a longer half-life developed by modifying the chemical structure of exenatide. This study aims to assess the efficacy and safety of PEX168 and determine the best dose. We searched PubMed, Scopus, Cochrane Library, and Web of Science databases from inception to April 25, 2023, for randomized controlled trials (RCTs) comparing PEX168 therapy alone or in combination with metformin versus other therapies. We used the risk ratio (RR) for dichotomous outcomes and the mean difference (MD) for continuous outcomes, both with 95% confidence intervals (CI). Six RCTs, including 1248 participants, were included. PEX168 added to metformin was significantly better than metformin alone regarding fasting blood glucose (MD = −1.20, 95% CI (−1.78, − 0.62), p 0.05). Body weight was significantly reduced in obese diabetic patients receiving PEX168 compared to the control group (MD = −5.46, 95% CI (−7.90, − 3.01), p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
