Repurposing of conserved autophagy-related protein ATG8 in a divergent eukaryote

Autor:	Maude F. Lévêque, Hoa Mai Nguyen, Sébastien Besteiro
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	apicomplexa apicoplast ATG8 non canonical autophagy plastid Toxoplasma Biology (General) QH301-705.5
Zdroj:	Communicative & Integrative Biology, Vol 9, Iss 4 (2016)
Druh dokumentu:	article
ISSN:	1942-0889 19420889
DOI:	10.1080/19420889.2016.1197447
Popis:	Toxoplasma gondii and other apicomplexan parasites contain a peculiar non-photosynthetic plastid called the apicoplast, which is essential for their survival. The localization of autophagy-related protein ATG8 to the apicoplast in several apicomplexan species and life stages has recently been described, and we have shown this protein is essential for proper inheritance of this complex plastid into daughter cells during cell division. Although the mechanism behind ATG8 association to the apicoplast in T. gondii is related to the canonical conjugation system leading to autophagosome formation, its singular role seems independent from the initial catabolic purpose of autophagy. Here we also discuss further the functional evolution and innovative adaptations of the autophagy machinery to maintain this organelle during parasite division.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/432a22f4d2b8455aa3961036deb844b8 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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