Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation

Autor: Suthat Liangpunsakul, Evelyn Toh, Ruth A. Ross, Laura E. Heathers, Kristina Chandler, AdePeju Oshodi, Breann McGee, Elizabeth Modlik, Tobyn Linton, Darrin Mangiacarne, Claudie Jimenez, X. Charlie Dong, Li Wang, Wanzhu Tu, David E. Nelson
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-017-04669-7
Popis: Abstract It is unknown if LPS (lipopolysaccharides) and markers of immune activation, soluble CD14 (sCD14) and CD163 (sCD163) are associated with the quantity of alcohol consumption. 148 subjects were enrolled (97 excessive drinkers (ED) and 51 controls). Time Line Follow-Back questionnaire was used to quantify the amount of alcohol consumed. Serum LPS, sCD14, and sCD163 were measured. Peripheral blood mononuclear cells (PBMCs) were also isolated. Compared to controls, ED had higher total drinks in the past 30 days, higher levels of LPS, sCD14 and sCD163. The levels of serum LPS, sCD14, and sCD163 were higher among ED with recent alcohol consumption (last drink
Databáze: Directory of Open Access Journals
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