Studies towards optimising the isolation of diplonine, a neurotoxin isolated from cultures of Stenocarpella maydis (Berk.) Sacc.
| Autor: | Leendert D. Snyman, Bradley C. Flett, Rowina A. Schultz |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Onderstepoort Journal of Veterinary Research, Vol 81, Iss 1, Pp e1-e4 (2014) |
| Druh dokumentu: | article |
| ISSN: | 0030-2465 2219-0635 |
| DOI: | 10.4102/ojvr.v81i1.765 |
| Popis: | Diplonine, a mycotoxin that induces neurotoxic clinical signs in the guinea pig, resembling those occurring in cattle and sheep with diplodiosis, was isolated previously from a Stenocarpella maydisculture. Knowledge of the chemical properties of the toxin, which was characterised as a substituted ß-cyclopropylamino acid, enabled amendments in the present study to the initial steps of the isolation procedure. Extraction with water and fractionation by cation exchange chromatography improved the efficiency of isolation, potentially allowing the preparation of larger amounts of the toxin. |
| Databáze: | Directory of Open Access Journals |
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