Leukocyte DNA methylation in Alzheimer´s disease associated genes: replication of findings from neuronal cells
| Autor: | Ida K Karlsson, Alexander Ploner, Yunzhang Wang, Margaret Gatz, Nancy L Pedersen, Sara Hägg |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Epigenetics, Vol 18, Iss 1 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1559-2294 1559-2308 15592294 |
| DOI: | 10.1080/15592294.2022.2158285 |
| Popis: | Differences in gene-wide DNA methylation of the Alzheimer’s disease (AD)-associated genes BIN1, HLA-DRB5, SORL1, SLC24A4, and ABCA7 are reported to be associated with AD in post-mortem brain samples. We investigated whether the same associations could be found in leukocytes collected pre-mortem. Using cohort data of 544 Swedish twins (204 dementia diagnoses), we replicated the findings in HLA-DRB5 and SLC24A4 at P |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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