Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression

Autor:	Ju-Ha Kim, Jisung Hwang, Ji Hoon Jung, Hyo-Jung Lee, Dae Young Lee, Sung-Hoon Kim
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	FOXP proteins Molecular networks Noncoding RNAs Cellular immunotherapy Clinical implications and cancer progression Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular Cancer, Vol 18, Iss 1, Pp 1-19 (2019)
Druh dokumentu:	article
ISSN:	1476-4598
DOI:	10.1186/s12943-019-1110-3
Popis:	Abstract Though Forkhead box P (FOXP) transcription factors comprising of FOXP1, FOXP2, FOXP3 and FOXP4 are involved in the embryonic development, immune disorders and cancer progression, the underlying function of FOXP3 targeting CD4 + CD25+ regulatory T (Treg) cells and the dual roles of FOXP proteins as an oncogene or a tumor suppressor are unclear and controversial in cancers to date. Thus, the present review highlighted research history, dual roles of FOXP proteins as a tumor suppressor or an oncogene, their molecular networks with other proteins and noncoding RNAs, cellular immunotherapy targeting FOXP3, and clinical implications in cancer progression.
Databáze:	Directory of Open Access Journals
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