Facile ZnO NPs catalyzed synthesis of substituted 4-amino-6-(1H-benzimidazol-2-ylsulfanyl)benzene-1,3-dicarbonitrile new derivatives as Potent biological agents
| Autor: | R. Champa, K. A. Vishnumurthy, Yadav D. Bodke, H. S. BhojyaNaik, IttePushpavathi IttePushpavathi, N. D. Satyanarayan, B. N. Nippu |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Current Chemistry Letters, Vol 13, Iss 3, Pp 569-592 (2024) |
| Druh dokumentu: | article |
| ISSN: | 1927-7296 1927-730X |
| DOI: | 10.5267/j.ccl.2024.2.002 |
| Popis: | This study focuses on the efficient synthesis of series of substituted 4-amino-6-(1H-benzimidazol-2-ylsulfanyl) benzene-1,3-dicarbonitrile derivatives synthesized from aldehydes, propanedinitrile, substituted thiols and catalyzed by ZnO nanoparticles (ZnONPs). All the synthesized compounds have been characterized using different spectroscopic techniques such as FT-IR, 1H-NMR, C13-NMR and Mass. The compounds were evaluated for potential pharmacological applications, including antimicrobial, α-amylase inhibitory and anticancer activities. Computational calculations, DFT, in-silico molecular docking, and ADME-toxicologystudies were performed. ADMET studies indicated that all synthesized compounds adhered to Rule of five with good bioavailability. This research underscores the promising pharmacological prospects of the synthesized newbenzimidazole derivatives. |
| Databáze: | Directory of Open Access Journals |
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