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Abstract Aims Veno‐arterial extracorporeal membrane oxygenation (VA‐ECMO) is a life‐saving procedure for supporting patients with cardiogenic shock after cardiac surgery. This work aimed to analyse the impact of changes in blood lactate levels on the survival of patients on post‐cardiotomy ECMO (PC‐ECMO) and whether lactate clearance (LC) performs better than absolute lactate levels. Methods and Results We retrospectively analysed the data of adult patients who received PC‐ECMO at our centre between 2016 and 2022. The primary outcome was the in‐hospital mortality rate. Arterial lactate levels were measured at ECMO initiation, peak and 12 and 24 h after VA‐ECMO support. LC was calculated at 12 and 24 h. Out of 2368 patients who received cardiac surgeries, 152 (median age, 48 years; 57.9% of them were men) received PC‐ECMO. Of them, 48 (31.6%) survived and were discharged, while 104 (68.4%) died during the index hospitalization. Non‐survivors had higher frequencies of atrial fibrillation (41.35% vs. 12.5%, P 8.2 mmol/L, area under the receiver operating characteristic curve (AUROC): 0.868] and 24 h (>2.6 mmol/L, AUROC: 0.896) had the best performance, followed by LC‐T12 (14.35 mmol/L, AUROC: 0.828). The initial pre‐ECMO blood lactate (>6.25 mmol/L, AUROC: 0.731) had an acceptable ability to discriminate mortality but was less than the following measurements and clearance. Kaplan–Meier curves demonstrated that LC of |
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