Epigenome-wide effects of vitamin D on asthma bronchial epithelial cells
| Autor: | Nadia Boutaoui, Sandeep Puranik, Rong Zhang, Ting Wang, Daniel H. Hui, John Brehm, Erick Forno, Wei Chen, Juan C. Celedón |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Epigenetics, Vol 14, Iss 9, Pp 844-849 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1559-2294 1559-2308 15592294 |
| DOI: | 10.1080/15592294.2019.1622993 |
| Popis: | Vitamin D is a nutrient and a hormone with multiple effects on immune regulation and respiratory viral infections, which can worsen asthma and lead to severe asthma exacerbations. We set up a complete experimental and analytical pipeline for ATAC-Seq and RNA-Seq to study genome-wide epigenetic changes in human bronchial epithelial cells of asthmatic subjects, following treatment of these cells with calcitriol (vitamin D3) and Poly (I:C)(a viral analogue). This approach led to the identification of biologically plausible candidate genes for viral infections and asthma, such as DUSP10 and SLC44A1. |
| Databáze: | Directory of Open Access Journals |
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