| Autor: |
Aurelio Orta-Resendiz, Monica Viveros-Rogel, Luis L. Fuentes-Romero, Moises Vergara-Mendoza, Damaris P. Romero-Rodriguez, Monica Muñoz-Lopez, Martha L. Zancatl-Diaz, Elsa Y. Vidal-Laurencio, Roberto A. Rodriguez-Diaz, Luis E. Soto-Ramirez |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
International Journal of Infectious Diseases, Vol 100, Iss , Pp 184-192 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1201-9712 |
| DOI: |
10.1016/j.ijid.2020.08.044 |
| Popis: |
Objectives: This study investigated the correlations between the human immunodeficiency virus type 1 (HIV-1) reservoir and immune activation levels in chronic patients under fully suppressive antiretroviral therapy (ART). Methods: We quantified the HIV-1 proviral DNA and 2-long terminal repeat (2-LTR) circle loads from peripheral blood mononuclear cells, the levels of CD38+ and Ki-67+ T-cells, and the levels of interleukin 7 (IL-7) in a cohort of patients with more than 5 years of ART at enrollment and after 1 year. Results: Among 29 participants with a median of 8 years (inter-quartile range, 6.9–9.4) under suppressive ART, we found higher levels of CD8+ CD38+ T-cells after 1 year (P = .000). We determined weak and statistically non-significant correlations between the levels of immune activation and the proviral DNA loads in CD4+ and CD8+ T-cells. Ki-67+ T-cells declined but not significantly and there was no significant correlation with the proportion of CD38+. Plasmatic IL-7 did not consistently correlated with the CD38+ and Ki-67+ T-cells. Conclusions: We found weak but statistically non-significant correlations between the levels of T-cell activation and the proviral DNA and 2-LTR circle loads. These results suggest that mechanisms other than viral replication drive chronic versus early immune activation in the long term. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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