The Effect of Hydroalcoholic Extract of Glaucium Flavum on the Activity of Anti Oxidative Enzymes in the Heart and Brain of Alloxan Induced Diabetic Rats
| Autor: | A Khoshvaghti, G H Darya, F Hashemi, M Klantari, K Hushmandi |
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| Jazyk: | English<br />Persian |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 21, Iss 1, Pp 331-337 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1561-4107 2251-7170 |
| Popis: | BACKGROUND AND OBJECTIVE: Oxidative stress is the connection between diabetes and neuropathies and micro vascular disorders. This study was designed to investigate the effect of hydroalcoholic extract of Glaucium Flavum on the tissue activity of antioxidant enzymes in the heart and brain of Alloxan induced diabetic rats. METHODS: In this experimental study, 32 male rats were randomly divided into four groups of eight including control, diabetic, diabetic rats treated by Glaucium Flavum with dose of 500mg/kg and diabetic rats treated with Glibenclamide 5μg/kg. Diabetes was induced by single injection of 120mg/kg of Alloxan. After one month, activity of SOD, CAT and GPX were measured in the heart and brain tissues and analyzed. FINDINGS: Cardiac activity of all three enzymes in the diabetic + extract group were significantly higher than diabetic control (p |
| Databáze: | Directory of Open Access Journals |
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