| Autor: |
Minu Bajpai, Hari Kishan |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
National Board of Examinations Journal of Medical Sciences, Vol 1, Iss 8, Pp 484-496 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2583-7524 |
| DOI: |
10.61770/NBEJMS.2023.v01.i08.002 |
| Popis: |
Objective: The aim of the present study is to evaluate the role of urinary transforming growth factor – β1 (uTGF-β1) in congenital unilateral pelvi-ureteric junction obstruction (PUJO) upto the point of developing conventional indications for surgery and after pyeloplasty with the aim to explore the development of targeted therapeutic strategies aimed at modulating its effects and attenuating renal fibrosis. Methods: Sixty two children with unilateral pelvi-ureteric junction obstruction, consisting of 46 boys and 16 girls, with a mean age of 9.4 months forms the study group. Twenty three out of 62 (37.1%) developed indication for surgery after a mean follow-up of 24.2±3.7 months. The uTGF-β1 levels have been measured by ELISA at different points of intervals, i.e., before indications for surgery, at the development of indications for surgery and after surgical intervention and compared with children continued to followon without indications for surgery. Results: In children, who were continued to be followed up without indications for surgery, 39 had a mean baseline uTGF-β1 levels of 698.4mg/pg/Cr. which increased to 753.1mg/pg/Cr. (p valuie |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
