Content of Angiogenesis Markers of Insulin-Like Growth Factor-1 and Endostatin in Patients with Acute Myocardial Infarction in the Presence or Absence of Comorbid Obesity

Autor: Martovytskyi D., Shelest O., Kravchun P.
Jazyk: English<br />Russian<br />Ukrainian
Rok vydání: 2019
Předmět:
Zdroj: Львівський клінічний вісник, Vol 2-3, Iss 26-27, Pp 30-35 (2019)
Druh dokumentu: article
ISSN: 2306-4269
2520-2898
DOI: 10.25040/lkv2019.02.030
Popis: Introduction. The study of markers which would improve the stratification of risk and diagnosis of acute myocardial infarction, is of great importance. The aim of the study. To investigate the content of angiogenesis markers insulin-like growth factor-1 and endostatin in patients with acute myocardial infarction in the presence or absence of comorbid obesity. Materials and methods. The study involved 46 patients with acute myocardial infarction with concomitant obesity who were treated in the infarctional department of the Kharkiv City Clinical Hospital (average age 62.1 ± 6.9 years). 22 of them with acute myocardial infarction with comorbidant obesity and 24 patients ‒ acute myocardial infarction without obesity. The groups were comparable by sex and age. The control group consisted of 20 healthy persons of corresponding age and sex. Аcute myocardial infarction was diagnosed according to ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation, 2017. Obesity was diagnosed according to American association of clinical endocrinologists and American college of endocrinology clinical practice guidelines for comprehensive medical care of patients with obesity, 2016. The obesity was established by body mass index: 18.5 to 24.9 kg/m2 (normal weight) and 30.0 kg/m2 (obese). Results. In patients with acute myocardial infarction with obesity, the level of insulin-like growth factor was statistically significantly higher (p
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