| Autor: |
Daisuke Hayashi, Yoshiaki Kubota, Takuya Nishino, Yukihiro Watanabe, Yoshiki Iwade, Junya Matsuda, Katsuhito Kato, Shuhei Tara, Yuya Ise, Yu-ki Iwasaki, Kuniya Asai |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmaceutical Health Care and Sciences, Vol 10, Iss 1, Pp 1-8 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2055-0294 |
| DOI: |
10.1186/s40780-024-00357-7 |
| Popis: |
Abstract Background Guideline-directed medical therapy (GDMT) is important in heart failure management; however, polypharmacy itself may impact heart failure. Although measures against polypharmacy are needed, current discussion on unilateral drug tapering (including the drugs that should be tapered) is insufficient. In this study, we investigated the relationship between the number of prescribed GDMT drugs and prognosis in patients with heart failure. Methods In this single-centre retrospective study, 3,146 eligible patients with heart failure were included and divided into four groups based on the median number of prescribed GDMT drugs and the median number of drugs not included in the GDMT (ni-GDMT) at the time of hospital discharge. The definition of GDMT was based on various Japanese guidelines. The primary outcome was all-cause mortality within 3 years of hospital discharge. Results A total of 252 deaths were observed during the 3-year follow-up period. Kaplan–Meier analysis revealed that groups with GDMT drug count ≥ 5 and ni-GDMT drug count |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
Full text from SpringerLink