| Autor: |
Zdeněk Plichta, Yulia Kozak, Rostyslav Panchuk, Viktoria Sokolova, Matthias Epple, Lesya Kobylinska, Pavla Jendelová, Daniel Horák |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Beilstein Journal of Nanotechnology, Vol 9, Iss 1, Pp 2533-2545 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2190-4286 |
| DOI: |
10.3762/bjnano.9.236 |
| Popis: |
Doxorubicin-conjugated magnetic nanoparticles containing hydrolyzable hydrazone bonds were developed using a non-toxic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) coating, which ensured good colloidal stability in aqueous media and limited internalization by the cells, however, enabled adhesion to the cell surface. While the neat PHPMA-coated particles proved to be non-toxic, doxorubicin-conjugated particles exhibited enhanced cytotoxicity in both drug-sensitive and drug-resistant tumor cells compared to free doxorubicin. The newly developed doxorubicin-conjugated PHPMA-coated magnetic particles seem to be a promising magnetically targeted vehicle for anticancer drug delivery. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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