| Autor: |
Lei Wang, Xin Yang, Weiwei Zheng, Degang Huang, Yinchang Zhang, Huazheng He, Shouliang Xiong, Congming Li, Chao Wang, Haoran Lin, Pingbo Chen, Tingjun Ye, Xing Yang, Qiang Wang |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Materials Today Advances, Vol 20, Iss , Pp 100435- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2590-0498 |
| DOI: |
10.1016/j.mtadv.2023.100435 |
| Popis: |
Controlled immune response, enhanced osteogenesis, and antibacterial effect are essential for successful implanted biomaterials in the long-term. However, the previous research only considers one of the above-mentioned materials’ properties, and the potential synergetic effects are still unknown. Inspired by the mussel adhesion-mediated ions-coordinated strategy, a multifunctional coating integrated with bioactive Sr2+ and antibacterial Cu2+ was fabricated the multifunctional PEEK implants (PEEK-PDA-Sr/Cu). Compared to the uncoating PEEK, the PEEK implants with a multifunctional coating can regulate the M1 subtypes of macrophages to M2 subtypes due to the presence of Sr2+, which further promote the osteogenic differentiation of BMSCs. Even under the bacterial infection environment, the PEEK implants with a multifunctional coating can still enhance the osseointegration of bone implants due to the antibacterial properties of Cu2+. Taken together, PEEK implants with a multifunctional coating can provide an osteogenic immune microenvironment with enhanced osteogenesis and antibacterial property, which is essential for successful implantation in the long-term. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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