An in-solution snapshot of SARS-COV-2 main protease maturation process and inhibition

Autor: Gabriela Dias Noske, Yun Song, Rafaela Sachetto Fernandes, Rod Chalk, Haitem Elmassoudi, Lizbé Koekemoer, C. David Owen, Tarick J. El-Baba, Carol V. Robinson, The COVID Moonshot Consortium, Glaucius Oliva, Andre Schutzer Godoy
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-37035-5
Popis: The Main protease of SARS-CoV-2 is key for viral replication, but its maturation process is still not completely understood. Here, the authors not only reveal unique details from the first step of maturation, but also demonstrate how different classes of inhibitor can block this step.
Databáze: Directory of Open Access Journals