Success of early antiviral monotherapy with pegylated interferon α-2a for posttransplantation fibrosing cholestatic hepatitis C (a clinical case)
| Autor: | A. V. Chzhao, O. I. Andreitseva, V. E. Syutkin, A. O. Chugunov, K. R. Dzhagrayev, A. A. Saliyenko, I. V. Aleksandrova, V. V. Artamonov, E. A. Soldatov, L. V. Donova, I. E. Galankina, L. N. Zimina |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Трансплантология (Москва), Vol 0, Iss 2-3, Pp 69-74 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2074-0506 2542-0909 |
| DOI: | 10.23873/2074-0506-2011-0-2-3-69-74 |
| Popis: | The paper describes a case of posttransplantation fibrosing cholestatic hepatitis C (PFCHC) in a female patient whose transplant was preserved due to timely antiviral therapy (AVT). Its differential diagnosis primarily required that chronic graft rejection and biliary anastomotic stricture be excluded as a cause of dysfunction. PFCHC was proposed to be a possible cause of graft dysfunction on the basis of the clinical course of the disease, the presence of a very high viral load, intervals after orthotopic liver transplantation, the results of histological studies, and no signs of biliary hypertension. Antiviral monotherapy was initiated using pegylated interferon α-2a (Pegasys), which resulted in a considerable improvement and yielded complete early virological and biochemical responses to AVT. This allows one to hope to obtain a sustained virological response and to eliminate hepatitis C infection in the patient after termination of a 48-week course of therapy. |
| Databáze: | Directory of Open Access Journals |
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