| Popis: |
Carbon tetrachloride (CCl4) can be decomposed into free radicals, which cause lipid peroxidation, thereby damaging liver cells, and resulting in the death of aquatic animals. The present study was to investigate the recovery effect and possible mechanism of dietary curcumin against liver injury in Cyprinus carpio induced by CCl4. The experiment was divided into four groups. Two control groups were fed with a basal feed (the negative control, P1 and the positive control, P2), and two treatment groups were fed with feeds supplemented with 120 and 240 mg kg−1 for the entire 10-week study duration, respectively (P3 and P4). At the end of the feeding period, the CCl4 solution (CCl4 was dissolved in olive oil at 30 %, 0.5 mL per 100 g body weight) was injected into the abdominal cavity of P1, P3 and P4 groups. And the P2 group was injected with olive oil in the same proportion. On days 2, 3, 5 and 7 after CCl4 challenge, samples were taken separately to investigate the effect of curcumin on the liver injury induced by CCl4 in fish. Results showed that plasma alanine transaminase (ALT)and aspartate aminotransferase (AST) avtivities of fish increased significantly, relative to pre-challenge levels, 2 day after CCl4-challenge in P1, P3 and P4 groups (P |
