The role of the cell adhesion molecules (integrins / cadherins) in prostate cancer
| Autor: | Alexandros Drivalos, Athanasios G. Papatsoris, Michael Chrisofos, Eleni Efstathiou, Meletios A. Dimopoulos |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | International Brazilian Journal of Urology, Vol 37, Iss 3, Pp 302-306 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1677-5538 1677-6119 |
| DOI: | 10.1590/S1677-55382011000300002 |
| Popis: | During prostate carcinogenesis the cellular adhesion molecules, i.e.; integrins and cadherins mediate aberrant interactions between glandular epithelial cells and the extracellular matrix. Several integrin α subunits are down-regulated, while β subunits are up-regulated. The expression of several cadherins and catenins has specific prognostic value. There is an association between the expression of the E-cadherin/catenin complex and high grade prostate cancer. Clinical trials evaluating the efficacy of integrin antagonists are ongoing with promising results. In this article we update the role of integrins and cadherins in prostate carcinogenesis and evaluate the therapeutic potential of their manipulation. |
| Databáze: | Directory of Open Access Journals |
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