Cerebrovascular medin is associated with Alzheimer's disease and vascular dementia

Autor: Raymond Q. Migrino, Nina Karamanova, Seth Truran, Geidy E. Serrano, Hannah A. Davies, Jillian Madine, Thomas G. Beach
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)
Druh dokumentu: article
ISSN: 2352-8729
DOI: 10.1002/dad2.12072
Popis: Abstract Introduction Medin, an aging‐associated amyloidogenic protein, induces cerebrovascular dysfunction and inflammation. We investigated the relationship between cerebrovascular medin and Alzheimer's disease (AD) and vascular dementia (VaD). Methods Cerebral arteriole medin was quantified from 91 brain donors with no dementia (ND), AD, VaD, or combined AD and VaD. Correlation analyses evaluated the relationship between arteriole medin, and plaques, tangles, or white matter lesions (WML). Receiver operating characteristic and regression analyses assessed whether medin is predictive of AD or VaD versus other cerebrovascular pathologies (circle of Willis [CoW] atherosclerosis and cerebral amyloid angiopathy [CAA]). Results Arteriole medin was higher in those with AD, VaD, or combined AD/VaD versus ND (P
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