Azacitidine and lenalidomide as an alternative treatment for refractory acute myeloid leukemia: a case report
| Autor: | Juliana Todaro, Patrícia Weinschenker Bollmann, Edna Terezinha Rother, Auro del Giglio |
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| Jazyk: | angličtina |
| Předmět: | |
| Zdroj: | São Paulo Medical Journal, Vol 133, Iss 3, Pp 271-274 |
| Druh dokumentu: | article |
| ISSN: | 1806-9460 1516-3180 |
| DOI: | 10.1590/1516-3180.2012.6790006 |
| Popis: | CONTEXT:Refractory acute myeloid leukemia (AML) is a difficult disease to control with second or third-line chemotherapy regimens. In this report, we describe using azacitidine in combination with lenalidomide as salvage therapy.CASE REPORT:52-year-old female was diagnosed with refractory AML and high-risk cytogenetics: complex monosomal karyotype consisting of t (3, 3) in association with monosomy 7 and del 5q. Morphological remission associated with maintenance of the cytogenetic abnormality of chromosome 3 and disappearance of the abnormalities relating to chromosomes 5 and 7 was achieved after three cycles of combination therapy with azacitidine and lenalidomide.CONCLUSION:Azacitidine plus lenalidomide can be a therapeutic option for patients with refractory AML, as illustrated in this case. |
| Databáze: | Directory of Open Access Journals |
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