Autor: |
Bin Duan, Shaoqi Chen, Xiaojie Cheng, Qi Liu |
Jazyk: |
angličtina |
Rok vydání: |
2024 |
Předmět: |
|
Zdroj: |
Genome Biology, Vol 25, Iss 1, Pp 1-23 (2024) |
Druh dokumentu: |
article |
ISSN: |
1474-760X |
DOI: |
10.1186/s13059-024-03213-x |
Popis: |
Abstract With the rapid advancements in spatial transcriptome sequencing, multiple tissue slices are now available, enabling the integration and interpretation of spatial cellular landscapes. Herein, we introduce SpaDo, a tool for multi-slice spatial domain analysis, including modules for multi-slice spatial domain detection, reference-based annotation, and multiple slice clustering at both single-cell and spot resolutions. We demonstrate SpaDo’s effectiveness with over 40 multi-slice spatial transcriptome datasets from 7 sequencing platforms. Our findings highlight SpaDo’s potential to reveal novel biological insights in multi-slice spatial transcriptomes. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
|