| Autor: |
Nobashi Tomomi, Saga Tsuneo, Nakamoto Yuji, Shimizu Yoichi, Koyasu Sho, Ishimori Takayoshi, Watanabe Masao, Kimura Hiroyuki, Togashi Kaori |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Endocrine Regulations, Vol 52, Iss 4, Pp 185-191 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1336-0329 |
| DOI: |
10.2478/enr-2018-0023 |
| Popis: |
Objective. This study investigated whether the metformin (Met)-induced enhanced intestinal uptake of 2-deoxy-2-[18F]fluoro-D-glucose (18F-FDG) is reduced by loperamide, a long-acting anti-diarrheal agent. Methods. Mean 18F-FDG uptake in the mouse small intestine and colon with Met exposure was compared with that in control mice. In the Met group, high-dose (1.0 mg/kg body weight) and low-dose (0.1 mg/kg body weight) loperamide were introduced, and 18F-FDG uptake in the small intestine and colon was compared with that of control mice administered high-dose loperamide. The percent injected dose of 18F-FDG per gram of tissue (%ID/g) in the extracted tissues was then determined. Results. 18F-FDG uptake increased significantly in the small intestine (0.64±0.06 vs. 1.01±0.15, p=0.040) and, especially, the colon (0.46±0.13 vs. 2.16±0.51, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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