| Autor: |
P Fitscha, A Keiler, J O'Grady, J C Igweh, B A Peskar, H Sinzinger |
| Jazyk: |
angličtina |
| Rok vydání: |
2001 |
| Předmět: |
|
| Zdroj: |
International Journal of Medicine and Health Development, Vol 6, Iss 1, Pp 32-36 (2001) |
| Druh dokumentu: |
article |
| ISSN: |
2635-3695 |
| Popis: |
Aim: To examine the effect of isradipine, a member of the dihydrophyridine family of calcium antagonists, on aortic and iliac wall thrombogenicity Materials and Methods: After one week of dosing, the abdominal aorta and iliac artery endothelium was abraded using fogarthy catheter. Aortic and iliac thrombogenicity was assessed, after perfusion in situ, by morphological quantification of platelet deposition using the Baumgartner technique as well as by counting the radioactivity after radiolabeling of autologous platelets with 111 in-oxine. One group of animals (n=8) were dosed for one week with isradipine 0.3 mg/kg. A second group of animals received 50mg acetylsalicylic acid (A.S.A) daily in addition, while a third group received the vehicle only. Finally a fourth group of animals (n=8) were treated with aspirin only. Results: The percentage of the denuded surface covered with contact (unspread) platelets decreased significantly (*p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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