| Autor: |
María Lemus-Peña, Abigail Hernandez-Barragan, Daniel Montes de Oca-Ángeles, Marisela Hernandez-Santillan, Daniel Santana-Vargas, Moisés Martinez-Castillo, Zaira Medina-Avila, Aldo Torre-Delgadillo, José Luis Pérez-Hernández, Fátima Higuera-De la Tijera, Paula Cordero-Pérez, Linda Muñoz-Espinosa, David Kershenobich, Gabriela Gutiérrez-Reyes |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Annals of Hepatology, Vol 28, Iss , Pp 100919- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1665-2681 |
| DOI: |
10.1016/j.aohep.2023.100919 |
| Popis: |
Introduction and Objectives: It has already been reported that elevated serum levels were present in Hepatitis C patients, although they were found inactive. The behavior of gelatinases MMP-2 and -9 is yet unknown in other liver diseases. This study aimed to evaluate serum concentration of MMP-2 and -9 in different etiologies of liver disease also according to fibrosis stages. Materials and Methods: Cross-sectional multicentric study, including subjects with no alcoholic fatty liver disease (NAFLD), chronic Hepatitis C (CHC), alcohol cirrhosis (CiOH) and alcoholism (OH), groups with alcohol drinking habits were classified according to WHO criteria, with clinical and biochemical evidence of alcoholic liver disease (ALD). Transient elastography (Fibroscan) was performed in NAFLD and CHC, considering mild fibrosis (FL: F0, F1, F2) and severe fibrosis (FA: F3, F4). As controls, subjects without alcohol consumption (CT) were recruited. Multiplex®-MERCK© was used for MMP-2 and -9 quantification. Statistical analysis was performed by Mann Whitney-U test, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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