| Autor: |
Sibel Bulgurcuoglu Kuran, Emine Hande Karagedik, Cem Iyibozkurt, Elif Sinem Iplik, Bedia Cakmakoglu, Arzu Ergen |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Medicine Science, Vol 7, Iss 4, Pp 762-5 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2147-0634 |
| DOI: |
10.5455/medscience.2018.07.8870 |
| Popis: |
Endometrial carcinoma is a metastatic and recurrent disease has a worse prognosis. We aim to investigate the MMP-3 gene polymorphism in Turkish patients with endometrial carcinoma. In recent years, number of genetic studies have been increased to find new prognostic and theraupeutic markers. Matrix metalloproteinases [MMPs] are proteolytic enzymes that degrade all components of the extracellular matrix which are play an important role of cancer metastasis and invasion. MMP-3, also known as stromelysin-1, to lyse basal membrane collagen and induce the synthesis of some other MMPs. 97 patients with endometrial carcinoma and 100 healthy controls were included in this study. MMP-3 E45K polymorphism was determined using polymerase chain reaction/ restriction fragment length polymorphism in study groups.There were no significant differences between any genotypes or allele in control and patient groups for MMP-3 E45K polymorphism. Besides no significant correlation was found between MMP-3 E45K polymorphisms and clinical characteristics, such as histology, grade, metastasis and family history. ur study suggests that the MMP-3 E45K polymorphism is not associated with endometrial carcinoma process in Turkish patients. [Med-Science 2018; 7(4.000): 762-5] |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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