Memory B cells and long-lived plasma cells in AMR

Autor:	Wenlong Yue, Jia Liu, Xiaohu Li, Luman Wang, Jinfeng Li
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Antibody-mediated rejection memory B cells long-lived plasma cells Diseases of the genitourinary system. Urology RC870-923
Zdroj:	Renal Failure, Vol 44, Iss 1, Pp 1604-1614 (2022)
Druh dokumentu:	article
ISSN:	0886022X 1525-6049 0886-022X
DOI:	10.1080/0886022X.2022.2128374
Popis:	Antibody-mediated rejection (AMR) has a strongly negative impact on long-term renal allograft survival. Currently, no recognized effective treatments are available, especially for chronic antibody-mediated rejection (CAMR). Donor-specific antibodies (DSAs) secreted by long-lived plasma cells and memory B cells are acknowledged as biomarkers of AMR. Nevertheless, it may be too late for the DSA routine examination production since DSAs may have binded to graft vascular endothelial cells through complement-dependent or complement-independent pathways. Therefore, methods to effectively monitor memory B cells and long-lived plasma cells and subsequently prevent DSA production are key to reducing the adverse effects of AMR. Therefore, this review mainly summarizes the production pathways of memory B cells and long-lived plasma cells and provides suggestions for the prevention of AMR after transplantation.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/423cb5f0220d4d71ba234dc5e1187ba8 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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