Stem cells in gastroenterology: prospects and problems
| Autor: | A. O. Buyeverov, V. T. Ivashkin |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии, Vol 21, Iss 6, Pp 4-11 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1382-4376 2658-6673 |
| Popis: | The aim of review. To generalize cumulative data on the role of stem cells (SC) in treatment of gastroenterological diseases.Original positions. Cell-based treatment is rather new and, probably, promising trend in treatment of many severe diseases in which traditional methods fail to achieve due results. In therapeutic aspect of gastrointestinal and liver diseases inflammatory bowel diseases, colorectal cancer and decompensated liver cirrhosis seem to be most perspective at the present stage. At the same time clinical application of SC is associated to array of serious problems: immune rejection and «graft-versus-host» response, neoplastic transformation as well as ethical and religious restrictions. Conclusion. Application SC in clinical gastroenterology is premature today. Their efficacy and safety requires confirmation in multicenter randomized trials. |
| Databáze: | Directory of Open Access Journals |
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