Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry

Autor:	Edward E. Large, Mark A. Silveria, Grant M. Zane, Onellah Weerakoon, Michael S. Chapman
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	adeno-associated virus AAV gene therapy virus structure AAV receptor AAV attachment factor Microbiology QR1-502
Zdroj:	Viruses, Vol 13, Iss 7, p 1336 (2021)
Druh dokumentu:	article
ISSN:	1999-4915
DOI:	10.3390/v13071336
Popis:	Human gene therapy has advanced from twentieth-century conception to twenty-first-century reality. The recombinant Adeno-Associated Virus (rAAV) is a major gene therapy vector. Research continues to improve rAAV safety and efficacy using a variety of AAV capsid modification strategies. Significant factors influencing rAAV transduction efficiency include neutralizing antibodies, attachment factor interactions and receptor binding. Advances in understanding the molecular interactions during rAAV cell entry combined with improved capsid modulation strategies will help guide the design and engineering of safer and more efficient rAAV gene therapy vectors.
Databáze:	Directory of Open Access Journals
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