| Autor: |
Viorela Mihaela Ciortea, Monica Ileana Borda, Irina Motoașcă, Sergiu Șușman, Alina Deniza Ciubean, Alina Liliana Pintea, Rodica Ana Ungur, Mădălina Gabriela Iliescu, Laszlo Irsay |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Balneo and PRM Research Journal, Vol 13, Iss 1, p 493 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2734-8458 |
| DOI: |
10.12680/balneo.2022.493 |
| Popis: |
Background. Melatonin, N-acetyl-5-methoxy-tryptamine is the major secretion product of the pineal gland with important anti-inflammatory and antioxidant properties, also being an im-portant marker of bone remodelling associated with menopause. Objectives. The aim of our study was to evaluate the effect of the co-administration of melatonin and estrogen on systemic inflammatory status and bone histopathological modifications in surgically induced menopau-sal female rats. Materials and methods. The study was performed on a number of 40 female rats, Wistar breed, which underwent bilateral surgical ovariectomy. Within 14 days postoperative, hormone replacement therapy with estrogen or estrogen with melatonin was initiated, in differ-ent doses. The treatment was administered for 12 consecutive weeks. At the end of the treatment we measured the serum levels of IL-6 and TNF-α. The femoral bones were harvested after sacri-ficing the animals and the thickness of the cortical bones was measured and histologically ana-lysed. Results. Serum values of inflammatory markers were negatively correlated with melatonin ad-ministration, the differences being more important at higher doses of melatonin (for both IL-6 and TNF-α the difference between group E_2M with estrogen substitution and melatonin in double dose and control group W, without hormone replacement, was highly statistically signif-icant with p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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