Comparative Assessment of E-cadherin’s Expression between the Metastatic and Non-metastatic Oral Squamous Cell Carcinoma: An Immunohistochemical Study
| Autor: | Sufia Khan, Veda Hegde, Deepti Shrivastava, Mohammed Azamulla, Mohammad Khursheed Alam, Kumar Chandan Srivastava |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Pesquisa Brasileira em Odontopediatria e Clínica Integrada, Vol 23 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1519-0501 1983-4632 |
| Popis: | Objective: To identify the clinicopathological correlation of E-cadherin expression in metastatic and non-metastatic oral squamous cell carcinoma (OSCC). Material and Methods: A total of 90 paraffin-embedded tissue sections of OSCC were retrieved from the registry. The total selected samples were 45 cases each from the primary lesions of metastatic and non-metastatic OSCC. One section was subjected to routine Hematoxylin and eosin stain and another to immunohistochemical analysis for E-cadherin expression. Results: A non-significant (p˃0.05) increased expression is seen in the non-metastatic group compared to the metastatic group, with predominantly membrane as the staining site in either group. However, the expression of E-cadherin did not reveal any statistically significant association with independent variables such as age, gender, and adverse habits of the patients (p>0.05). On the other hand, with respect to the histological differentiation of OSCC, a significant association (p |
| Databáze: | Directory of Open Access Journals |
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