Immune‐mediated axonal dysfunction in seropositive and seronegative primary Sjögren’s syndrome

Autor: Jowy Tani, Hsien‐Tzung Liao, Hui‐Ching Hsu, Lung‐Fang Chen, Tsui‐San Chang, Cindy Shin‐Yi Lin, Jia‐Ying Sung
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Annals of Clinical and Translational Neurology, Vol 7, Iss 5, Pp 819-828 (2020)
Druh dokumentu: article
ISSN: 2328-9503
DOI: 10.1002/acn3.51053
Popis: Abstract Objective The present study investigates the peripheral neuropathy in Primary Sjögren's syndrome (pSS) using the nerve excitability test to further elucidate how peripheral nerves are affected by the autoantibodies. Methods Each patient received clinical evaluation, examination for anti‐SSA/Ro and anti‐SSB/La antibodies titer, paired motor and sensory nerve excitability test, thermal quantitative sensory test (QST), and nerve conduction study (NCS). Results A total of 40 pSS patients wasenrolled. Motor axonal study of the pSS with positive anti‐SSA/Ro or anti‐SSB/La antibodies (n = 28) was found to have increased stimulus for 50% compound muscle action potential (CMAP) (P
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