| Autor: |
Utkarsh Jindal, Mehak Sood, Anirban Dutta, Shubhajit Roy Chowdhury |
| Jazyk: |
angličtina |
| Rok vydání: |
2015 |
| Předmět: |
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| Zdroj: |
IEEE Journal of Translational Engineering in Health and Medicine, Vol 3, Pp 1-12 (2015) |
| Druh dokumentu: |
article |
| ISSN: |
2168-2372 |
| DOI: |
10.1109/JTEHM.2015.2389230 |
| Popis: |
This paper presents a point of care testing device for neurovascular coupling (NVC) from simultaneous recording of electroencephalogram (EEG) and near infrared spectroscopy (NIRS) during anodal transcranial direct current stimulation (tDCS). Here, anodal tDCS modulated cortical neural activity leading to hemodynamic response can be used to identify the impaired cerebral microvessels functionality. The impairments in the cerebral microvessels functionality may lead to impairments in the cerebrovascular reactivity (CVR), where severely reduced CVR predicts the chances of transient ischemic attack and ipsilateral stroke. The neural and hemodynamic responses to anodal tDCS were studied through joint imaging with EEG and NIRS, where NIRS provided optical measurement of changes in tissue oxy-(HbO2) and deoxy-(Hb) hemoglobin concentration and EEG captured alterations in the underlying neuronal current generators. Then, a cross-correlation method for the assessment of NVC underlying the site of anodal tDCS is presented. The feasibility studies on healthy subjects and stroke survivors showed detectable changes in the EEG and the NIRS responses to a 0.526 A/m2 of anodal tDCS. The NIRS system was bench tested on 15 healthy subjects that showed a statistically significant (p 2 response in one of the stroke survivors with white matter lesions. Therefore, it was concluded that the anodal tDCS can perturb the local neural and the vascular activity (via NVC) which can be used for assessing regional NVC functionality where confirmatory clinical studies are required. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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