NEUROPEPTIDES (SP AND CGRP) AUGMENT IL-1 BETA PRODUCTION IN HSV-INFECTED MACROPHAGES
| Autor: | Roya Yaraee, Massoumeh Ebtekar, A. Ahmadiani, Farzanch Sabahi |
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| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: | |
| Zdroj: | Iranian Journal of Allergy, Asthma and Immunology, Vol 2, Iss 2 (2003) |
| Druh dokumentu: | article |
| ISSN: | 1735-1502 1735-5249 |
| Popis: | Neuropeptides, possessing specific and functional receptors on various cells of the immune system, have the potential to regulate immune responses; and the macrophages as important components of defense against various agents, are at their influence. In this study the effect of neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) on IL-1 beta production by herpes sim¬plex type-1 (HSV-1 )-infected and also uninfected mouse peritoneal macrophages were considered. Each neuropeptide separately has upregulated IL-1 beta produc¬tion by HSV-1 infected macrophages with the greatest effect at the concentrations of 10'9M for both SP and CGRP, but no synergistic effect on IL-1 production has been observed in the presence of both neuropeptides at optimal concentrations. IL-ip production by uninfected macrophages was also moderately enhanced in the presence of each neuropeptide, but not in the presence of both neuropeptides simultaneously. It can be concluded that IL-1 S3 production, which is part of mac¬rophage mediated inflammatory response to HSV-1, is enhanced by specific doses of neuropeptides. |
| Databáze: | Directory of Open Access Journals |
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