| Autor: |
Zaineb Amjid, Shoaib Khan, Tayyiaba Iqbal, Rafaqat Hussain, Hafeeza Zafar Ali, Khurram Shoaib, Yousaf Khan, Hayat Ullah, Sabeen Arshad, Rashid Iqbal, Riaz Ullah, Essam A. Ali |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Results in Chemistry, Vol 11, Iss , Pp 101744- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2211-7156 |
| DOI: |
10.1016/j.rechem.2024.101744 |
| Popis: |
In this study we have adopted a new synthetic route for different substituted Schiff base derivatives (1–10) and examined their anti-diabetic potential. All these compounds exhibited a varied range against α-amylase and α-glucosidase with antidiabetic potential. Analog (6) with triflouro methyl substituent, present on the para position of the ring was emerged as most potent compound. Acarbose was used as reference drug with IC50 = 6.80 ± 0.40 μM and 7.20 ± 0.70 μM for α-amylase and α-glucosidase, respectively. Furthermore, antibacterial and antifungal activity of these compounds was also evaluated against E. coli and A. alternate in the presence of marketed drug Terbinafine and Streptomycin. Binding modalities of synthesized compounds with the receptor residues of target enzymes were explored by in silico docking. Additionally, ADME analysis and DFT were also conducted to assess the drug-like characteristics and electronic properties of the potent derivatives. The synthesized compounds were confirmed through spectroscopic techniques such as 13C NMR, 1H NMR and HREI-Mass spectrometry. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
