Transforming Growth Factor Beta 1 and Vascular Endothelial Growth Factor Levels in the Pathogenesis of Periodontal Disease
| Autor: | G. Matarese, G. Isola, G.P. Anastasi, G. Cutroneo, G. Cordasco, A. Favaloro, G. Vita, G. Vermiglio, D. Milardi, V.L. Zizzari, S. Tetè, L. Perillo |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | European Journal of Inflammation, Vol 11 (2013) |
| Druh dokumentu: | article |
| ISSN: | 1721-727X 1721727X |
| DOI: | 10.1177/1721727X1301100217 |
| Popis: | Periodontal disease is characterized by inflammation and bone loss. The balance between inflammatory mediators and their counter-regulatory molecules may be fundamental for determining the outcome of immune pathology of periodontal disease. Cytokines play crucial roles in the maintenance of tissue homeostasis, a process which requires a delicate balance between anabolic and catabolic activities. In particular, two families of growth factors-such as transforming growth factor-β1 (TGF-β1) and vascular endothelial growth factor (VEGF) are thought to play important roles in modulating the proliferation and/or migration of structural cells involved in inflammation and regulation of immune responses. The aim of this work was to analyze gingival samples and periodontal tissue specimens collected from thirty-eight patients with chronic periodontal disease and from forty healthy individuals, in order to detect the expression and distribution of TGF-β1 and VEGF between the two groups. TGF-β1 and VEGF expression levels were detected using immunohistochemical analysis and computer-assisted morphometric analysis. The findings presented here suggest that biomarker such as TGF-β1 and VEGF have an important regulating role in the orchestration of the immune response, which in turn influence the outcome of disease establishment and evolution. |
| Databáze: | Directory of Open Access Journals |
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