Principles of Functional Circuit Connectivity: Insights From Spontaneous Activity in the Zebrafish Optic Tectum

Autor: Emiliano Marachlian, Lilach Avitan, Geoffrey J. Goodhill, Germán Sumbre
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Frontiers in Neural Circuits, Vol 12 (2018)
Druh dokumentu: article
ISSN: 1662-5110
DOI: 10.3389/fncir.2018.00046
Popis: The brain is continuously active, even in the absence of external stimulation. In the optic tectum of the zebrafish larva, this spontaneous activity is spatially organized and reflects the circuit’s functional connectivity. The structure of the spontaneous activity displayed patterns associated with aspects of the larva’s preferences when engaging in complex visuo-motor behaviors, suggesting that the tectal circuit is adapted for the circuit’s functional role in detecting visual cues and generating adequate motor behaviors. Further studies in sensory deprived larvae suggest that the basic structure of the functional connectivity patterns emerges even in the absence of retinal inputs, but that its fine structure is affected by visual experience.
Databáze: Directory of Open Access Journals