COVID-19 Infection in Children, Infants and Pregnant Subjects: An Overview of Recent Insights and Therapies

Autor: Giuseppina Malcangi, Alessio Danilo Inchingolo, Angelo Michele Inchingolo, Luigi Santacroce, Grazia Marinelli, Antonio Mancini, Luigi Vimercati, Maria Elena Maggiore, Maria Teresa D’Oria, Denisa Hazballa, Ioana Roxana Bordea, Edit Xhajanka, Antonio Scarano, Marco Farronato, Gianluca Martino Tartaglia, Delia Giovanniello, Ludovica Nucci, Rosario Serpico, Gilberto Sammartino, Loredana Capozzi, Antonio Parisi, Marina Di Domenico, Felice Lorusso, Maria Contaldo, Francesco Inchingolo, Gianna Dipalma
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Microorganisms, Vol 9, Iss 9, p 1964 (2021)
Druh dokumentu: article
ISSN: 2076-2607
DOI: 10.3390/microorganisms9091964
Popis: Background: The SARS-CoV-2 pandemic has involved a severe increase of cases worldwide in a wide range of populations. The aim of the present investigation was to evaluate recent insights about COVID-19 infection in children, infants and pregnant subjects. Methods: a literature overview was performed including clinical trials, in vitro studies, reviews and published guidelines regarding the present paper topic. A descriptive synthesis was performed to evaluate recent insights and the effectiveness of therapies for SARS-CoV-2 infection in children, infants and pregnant subjects. Results: Insufficient data are available regarding the relationship between COVID-19 and the clinical risk of spontaneous abortion and premature foetus death. A decrease in the incidence of COVID-19 could be correlated to a minor expression of ACE2 in childrens’ lungs. At present, a modulation of the dose-effect posology for children and infants is necessary. Conclusions: Pregnant vertical transmission has been hypothesised for SARS-CoV-2 infection. Vaccines are necessary to achieve mass immunity for children and also pregnant subjects.
Databáze: Directory of Open Access Journals