| Autor: |
Suchitra Monapati, Pavani Kaki, Mary Stella Gurajapu, Prathibha Guttal Subhas, Harinadha Baba Kudipudi |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Drugs and Drug Candidates, Vol 2, Iss 4, Pp 923-936 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2813-2998 |
| DOI: |
10.3390/ddc2040046 |
| Popis: |
The dietary reference levels for vitamin D were established with an emphasis on its role in bone health; however, with the identification of vitamin D receptors in all body tissues novel associations with other metabolic disorders, such as diabetes, are being researched. Aside from its standard function as the main regulator of calcium absorption, vitamin D also controls the calcium pool, mediates the activity of beta cell calcium-dependent endopeptidases, encourages the conversion of proinsulin to insulin, increases insulin output, and raises insulin activity in peripheral insulin target tissues. Both immune cells and pancreatic beta cells include vitamin D receptors. A deficiency of vitamin D causes glucose intolerance and affects insulin secretion. Different pathogenic characteristics of the disease are linked to a number of vitamin D-related genes. It has been proven that vitamin D supplementation lowers the risk of type 1 and type 2 diabetes and its associated problems. In this article, we discussed a few prospective clinical trials on vitamin D that are necessary to clearly demonstrate the role of vitamin D in the prevention and management of diabetes. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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