NF1 mutations as biomarker of response to immune checkpoint blockades for lung adenocarcinoma patients

Autor: Jean-Stéphane Giraud, Anne Jouinot, Eric Pasmant, Camille Tlemsani
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: npj Precision Oncology, Vol 8, Iss 1, Pp 1-6 (2024)
Druh dokumentu: article
ISSN: 2397-768X
DOI: 10.1038/s41698-024-00524-x
Popis: Abstract Little is known about immune checkpoint inhibitors (ICI) response of NF1-mutated lung adenocarcinomas. 341/4,181 (8.2%) TCGA lung adenocarcinomas samples have a somatic NF1 mutation. NF1-mutated tumors have higher TMB (p
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