A simpler noninvasive method of predicting markedly elevated pulmonary vascular resistance in patients with chronic thromboembolic pulmonary hypertension

Autor: Ya‐Nan Zhai, Ai‐Li Li, Xin‐Cao Tao, Wan‐Mu Xie, Qian Gao, Yu Zhang, Ai‐Hong Chen, Jie‐Ping Lei, Zhen‐Guo Zhai
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Pulmonary Circulation, Vol 12, Iss 3, Pp n/a-n/a (2022)
Druh dokumentu: article
ISSN: 2045-8940
DOI: 10.1002/pul2.12102
Popis: Abstract Several echocardiographic methods to estimate pulmonary vascular resistance (PVR) have been proposed. So far, most studies have focused on relatively low PVR in patients with a nonspecific type of pulmonary hypertension. We aimed to clarify the clinical usefulness of a new echocardiographic index for evaluating markedly elevated PVR in chronic thromboembolic pulmonary hypertension (CTEPH). We studied 127 CTEPH patients. We estimated the systolic and mean pulmonary artery pressure using echocardiography (sPAPEcho, mPAPEcho) and measured the left ventricular internal diameter at end diastole (LVIDd). sPAPEcho/LVIDd and mPAPEcho/LVIDd were then correlated with invasive PVR. Using receiver operating characteristic curve analysis, a cutoff value for the index was generated to identify patients with PVR > 1000 dyn·s·cm−5. We analyzed pre‐ and postoperative hemodynamics and echocardiographic data in 49 patients who underwent pulmonary endarterectomy (PEA). In this study, mPAPEcho/LVIDd moderately correlated with PVR (r = 0.51, p 1000 dyn·s·cm−5 (area under curve = 0.804, p
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