Nutritional Status and Other Baseline Predictors of Mortality among HIV-Infected Children Initiating Antiretroviral Therapy in Tanzania
| Autor: | Ramadhani S. Mwiru ScD, Donna Spiegelman ScD, Christopher Duggan MPH, George R. Seage ScD, Helen Semu MPH, Guerino Chalamilla PhD, Rodrick Kisenge PhD, Wafaie W. Fawzi DrPH |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Journal of the International Association of Providers of AIDS Care, Vol 14 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2325-9574 2325-9582 23259574 |
| DOI: | 10.1177/2325957413500852 |
| Popis: | Background: We assembled a prospective cohort of 3144 children less than 15 years of age initiating antiretroviral therapy (ART) in Dar es Salaam, Tanzania. Methods: The relationships of nutritional status and other baseline characteristics in relation to mortality were examined using Cox proportional hazards model. Results: Compared with children with weight for age (WAZ) > -1, those with WAZ ≤ -2 to < -3 had a nearly double risk of death (relative risk [RR], 1.85; 95% confidence interval [CI], 1.10-3.11), and among those with WAZ ≤ -3, the risk more than tripled (RR, 3.36; 95% CI, 2.12-5.32). Other baseline risk factors for overall mortality included severe anemia ( P < .001), severe immune suppression ( P = .02), history of tuberculosis ( P = .01), opportunistic infections ( P < .001), living in the poorest district ( P < .001), and advanced World Health Organization stage ( P = .003). Conclusions: To sustain the obtained benefit of ART in this setting, interventions to improve nutritional status may be used as an adjunct to ART. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|