| Autor: |
Bogdan Obrișcă, Valentin Mocanu, Roxana Jurubiță, Alexandra Vrabie, Andreea Berechet, Ștefan Lujinschi, Bogdan Sorohan, Andreea Andronesi, Camelia Achim, Gabriela Lupușoru, Georgia Micu, Nicu Caceaune, Mihaela Gherghiceanu, Gener Ismail |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
BMC Nephrology, Vol 25, Iss 1, Pp 1-14 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2369 |
| DOI: |
10.1186/s12882-024-03577-z |
| Popis: |
Abstract Background There is a clear need to refine the histological assessment in IgA Nephropathy (IgAN). We sought to investigate the clinical significance of the light microscopy (LM) pattern of glomerular injury and of the intensity of mesangial C3 staining in IgAN. Methods We conducted a retrospective, observational study that included all patients with biopsy-proven primary IgAN that had at least 12 months of follow-up. The LM pattern of glomerular injury was reevaluated based on a modified HAAS classification. Mesangial C3 deposition by immunofluorescence (IF) staining was scored semi-quantitatively. The study primary composite endpoint was defined as doubling of serum creatinine or ESRD (dialysis, renal transplant or eGFR |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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